Surgical Treatment of Primary Localized Cutaneous Nodular Amyloidosis of the Nose: Resection and Reconstruction With a Nasolabial Flap.

Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare form of amyloidosis limited to the skin. A 39-year-old woman had noticed a tumor on her right nasal ala for five years. She presented it to our hospital after developing a similar lesion on her right cheek. Histopathological examination following surgical excision revealed AL amyloidosis (κ-light chain type), ruling out systemic amyloidosis and confirming the diagnosis of PLCNA. The nasal lesion was excised and reconstructed with a nasolabial flap, resulting in excellent aesthetic and functional outcomes. No recurrence has been observed during a 21-month follow-up. PLCNA in young adults is rare, and long-term follow-up is crucial due to the potential for systemic progression. This case highlights the importance of accurate diagnosis and the benefits of local flap reconstruction in cosmetically sensitive areas.