Invasive Pneumococcal Disease Presenting as Austrian Syndrome in a Patient With HIV Infection: A Case Report.

Austrian syndrome is a rare and severe manifestation of invasive Streptococcus pneumoniae infection, defined by the triad of pneumonia, meningitis, and infective endocarditis. Although it is uncommon in the modern antibiotic and vaccination era, Austrian syndrome is associated with significant morbidity and mortality. Here we present a case of a 62-year-old male with a history of human immunodeficiency virus infection and intravenous drug use who presented with cough, fatigue, and left upper extremity weakness. He developed acute hypoxic respiratory failure and status epilepticus requiring intubation. Workup revealed bibasilar pneumonia, S. pneumoniae bacteremia, and pneumococcal meningitis confirmed via cerebrospinal fluid analysis. Echocardiography demonstrated tricuspid valve vegetation consistent with endocarditis. The patient was managed with broad-spectrum intravenous antibiotics, which were subsequently de-escalated based on culture sensitivity. Surgical intervention was not opted for due to the size and location of the vegetations. The patient completed a six-week course of ceftriaxone and vancomycin with clinical improvement and negative follow-up blood cultures. This case explains the importance of maintaining a high index of suspicion for Austrian syndrome in high-risk populations presenting with systemic symptoms. Early recognition, microbiological and radiological confirmation, and aggressive antibiotic therapy are essential for a favorable outcome. Despite its rarity, awareness of this condition and adherence to evidence-based management can significantly improve survival in affected patients.