Anetoderma Presenting as Neoplasms of Uncertain Behavior in an Elderly Female: A Case Report.

Anetoderma is a rare cutaneous disorder characterized by focal loss of dermal elastic tissue, often presenting as atrophic or herniated plaques. However, clinical presentations can vary, and atypical forms may resemble neoplastic or inflammatory lesions, complicating diagnosis. We present the case of a 78-year-old female who was evaluated for asymptomatic skin growths on the posterior neck, chest, and torso, reported to have been present for five years and slowly spreading. On physical examination, firm papules and subcutaneous nodules were noted on the left rib cage, left medial breast, and mid-trapezial neck. The lesions were initially diagnosed clinically as neoplasms of uncertain behavior, and two were biopsied using the punch method. Histopathology from the left rib cage revealed anetoderma, prompting reassurance and conservative management. At follow-up, anetoderma was also identified on the right medial superior chest. The patient remained asymptomatic, with no new lesions reported. This case highlights an uncommon presentation of anetoderma masquerading as subcutaneous neoplasms in an elderly patient with no known systemic disease or identifiable preceding dermatosis. It underscores the importance of histopathologic confirmation when evaluating lesions of uncertain behavior and expands the clinical spectrum of anetoderma, particularly in older adults. Given the lack of effective treatment options, accurate diagnosis is essential for guiding appropriate patient counseling and avoiding unnecessary interventions.