A Meta-Analysis of the Impact of Mindfulness-Based Stress Reduction Therapy Intervention on Post-traumatic Stress Disorder.

This meta-analysis was conducted to investigate the effect of mindfulness-based stress reduction (MBSR) on the treatment and improvement of traumatic stress disorder (PTSD). Up until February 6, 2025, PubMed, Web of Science, and Embase databases were searched for randomized controlled trials of MBSR-based treatment for PTSD patients. RevMan 5.4 software (The Cochrane Collaboration, London, UK) was used to conduct a meta-analysis of these trials. A total of 832 participants from nine qualified randomized controlled trials were enrolled. Meta-analysis results showed that in PTSD patients, depression scores after Mindfulness-Based Stress Reduction (MBSR) intervention were significantly lower compared with the control group (Standardized Mean Difference (SMD) = -0.25, 95% CI -0.39 to -0.10; P = 0.0006). Quality of life (SMD = 0.40, 95% CI 0.10-0.70; P = 0.008) and Five Facet Mindfulness Questionnaire (SMD = 0.41, 95% CI 0.24-0.57; P < 0.00001) scores were significantly higher than in the control group. PTSD symptoms (SMD = -0.20, 95% CI -0.31 to -0.09; P = 0.0003), various PTSD checklist scores (SMD = -1.28, 95% CI -0.33 to -0.03; P = 0.02), and clinician-administered PTSD scale scores (SMD = -0.23, 95% CI -0.39 to -0.07; P = 0.004) were also significantly reduced following MBSR intervention. MBSR can reduce depression, PTSD symptoms, and improve the quality of life and mindfulness in PTSD patients.