Journal of biomedical research
GPC6 facilitates progression of SHH-subgroup medulloblastoma by enhancing Hedgehog secretion and signaling responses.
Yue Wang, Qingyue Meng, Qin Zhu, Xinyi Zhang, Xinfa Wang, Junping He, Jing Cai, Xiaohong Pu, Zihe Ai, Qinya Li, Kedui Pu, Tingting Yu, Chen Liu, Shen Yue
Published: 202510.7555/JBR.39.20250406
Abstract
Medulloblastoma (MB) is the most common malignant tumor of the cerebellum in children. The SHH subgroup of MB (SHH-MB) is driven by aberrant activation of the Sonic Hedgehog (SHH) pathway; however, mutations in genes related to this pathway are relat…
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