eLifeMethylaminesAnimalsGastrointestinal MicrobiomeCircadian RhythmMice
Gut microbe-derived trimethylamine shapes circadian rhythms through the host receptor TAAR5.
Kala K Mahen, William J Massey, Danny Orabi, Amanda L Brown, Thomas C Jaramillo, Amy Burrows, Anthony J Horak, Sumita Dutta, Marko Mrdjen, Nour Mouannes, Venkateshwari Varadharajan, Lucas J Osborne, Xiayan Ye, Dante M Yarbrough, Treg Grubb
Published: 202610.7554/eLife.107037
Abstract
Elevated levels of the gut microbe-derived metabolite trimethylamine N-oxide (TMAO) are associated with cardiometabolic disease risk. However, the mechanism(s) linking TMAO production to human disease are incompletely understood. Initiation of the me…
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