eLifeProteostasisEndoplasmic ReticulumHydrazonesHumansActivating Transcription Factor 6
Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity.
Gabriel M Kline, Lisa Boinon, Adrian Guerrero, Sergei Kutseikin, Gabrielle Cruz, Marnie P Williams, Ryan J Paxman, William E Balch, Jeffery W Kelly, Tingwei Mu, R Luke Wiseman
Published: 202610.7554/eLife.107000
Abstract
Pharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically diverse protein misfolding diseases. However, despite this promise, few compounds have been identified that…
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