Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsHumansAttention Deficit Disorder with HyperactivityGastrointestinal MicrobiomeChildBrain
[The microbiota-gut-brain axis in childhood attention-deficit/hyperactivity disorder: mechanisms and therapeutic advances].
Ying-Lun Yuan, Yong-Mei Lan, Lin-Mei Guo
Published: 202510.7499/j.issn.1008-8830.2503118
Abstract
Open AccessAttention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children. Growing evidence links ADHD to gut microbiota dysbiosis, positioning the microbiota-gut-brain axis as a new focus of childhood ADHD research. This review systematically elucidates the association between gut dysbiosis and childhood ADHD and analyzes key mechanisms by which the microbiota-gut-brain axis regulates bidirectional gut-brain communication through multiple pathways. It highlights recent findings on microbiota-targeted strategies to improve ADHD symptoms and discusses therapeutic prospects, with the aim of exploring new avenues for early intervention and treatment in children with ADHD.