Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiologyHumansPolo-Like Kinase 1Myelodysplastic SyndromesProtein Serine-Threonine KinasesGlycine
Targeting PLK1 in myelodysplastic syndromes: The Role of Rigosertib in Precision Medicine.
Vedant Patil, Sujata Lambe, Anand Lokhande, Shivani Zanan, Siddhi Chandak
Published: 202510.62958/j.cjap.2025.021
Abstract
Rigosertib (ON 01910.Na) is a novel multi-kinase inhibitor initially developed as a non-ATP competitive agent, targeting dysregulated signalling pathways in cancer cells, notably RAS/RAF/MEK/ERK and PI3K/AKT, alongside Polo-like kinase 1 (PLK1). Prec…
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