Iranian biomedical journalFluorouracilHumansColonic NeoplasmsHT29 CellsModels
Genome-Scale Metabolic Modeling Identifies Synergistic Metabolites that Enhance 5-Fluorouracil Efficacy in Colon Cancer.
Hasan Rahimi-Tamandegani, Ayed-Amir Marashi, Ghazaleh Ghavami, Mahya Mehrmohamadi, Soroush Sardari
Published: 202510.61882/ibj.5178
Abstract
Background: Colon cancer remains a leading cause of cancer-related mortality, with the efficacy of standard chemotherapy agents such as 5-FU limited by resistance and toxicity. This study aimed to identify metabolites that enhance 5-FU efficacy in CR…
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