[Preventive Responses to Avian Influenza Human Infection in the Republic of Korea, 2022-2023].

Avian influenza (AI) infection in humans caused by AI viruses, such as H5N1, H7N9, and H9N2 is classified as a Category I National Notifiable Infectious Disease in the Republic of Korea (ROK). It manifests as an acute respiratory infection in patients who are exposed to infected birds or contaminated environments. This report describes the response outcomes of the Korea Disease Control and Prevention Agency (KDCA) to prevent the occurrence of AI infection in humans during the 2022-2023 season. In preparation for the 2022-2023 season, the KDCA operated the 'Central AI Infection in humans Response Task Force' and enhanced the capabilities of the local AI response personnel. Collaborative systems with relevant agencies, including the Ministry of Agriculture, Food and Rural Affairs, were strengthened and response guidelines were revised to incorporate the latest opinions. During the 2022-2023 season, highly pathogenic AI H5N1 cases were detected, including 75 cases of H5N1 in poultry and 174 cases in wild birds. Individuals classified as high risk for human infection, including culling participants, farm workers, and AI response personnel, totaled 6,373 individuals. Among them, six suspected cases have been reported. However, all the test results were negative, indicating that there were no confirmed cases of human infection in the ROK. To address the escalating risk of human infections in humans, the KDCA affirms its commitment to continually enhance both the central and local response frameworks. Furthermore, efforts will be directed towards reinforcing cross-agency collaborative systems based on a One Health approach.