Comparative Evaluation of Microhardness and Solubility after Addition of Two Different Combinations of Double Antibiotic Powders Containing Metronidazole + Ciprofloxacin and Metronidazole + Amoxicillin Clavulanate to a Bulk-fill Alkasite Material, Cention-N: An In Vitro Study.

Background: The incorporation of antibiotics into restorative materials has been shown to improve antibacterial effectiveness in previous studies. However, it remains uncertain whether such modifications could influence the mechanical properties of these materials. Materials and methods: Metal molds (10 mm diameter × 6 mm thickness) were fabricated and divided into three groups: Group I-Cention-N (control), group II-Cention-N combined with metronidazole + ciprofloxacin, and group III-Cention-N combined with metronidazole + amoxicillin-clavulanate. The prepared specimens were immersed in neutral and acidic artificial saliva for 21 days. Microhardness and solubility were assessed at 24 hours, 72 hours, 7 days, and 21 days. Results: In neutral saliva, all groups showed a gradual rise in microhardness values over 21 days. In acidic saliva, microhardness decreased for groups II and III, whereas group I exhibited a significant increase (p = 0.020). Solubility values were lowest in group III across both storage media. Conclusion: The incorporation of antibiotic powders into Cention-N resulted in reduced solubility without adversely affecting its microhardness, which remained comparable to the unmodified material. How to cite this article: Abhishek TS, Sogi HS, Jain M, et al. Comparative Evaluation of Microhardness and Solubility after Addition of Two Different Combinations of Double Antibiotic Powders Containing Metronidazole + Ciprofloxacin and Metronidazole + Amoxicillin Clavulanate to a Bulk-fill Alkasite Material, Cention-N: An In Vitro Study. Int J Clin Pediatr Dent 2025;18(S-1):S45-S53.