Application status of endoscopic anti-reflux mucosal interventions in the treatment of gastroesophageal reflux disease.

Prevalence of gastroesophageal reflux disease (GERD) has shown an upward trend over the years. Even though patients with GERD have a poor quality of life, the current treatment options are highly limited. In recent years, however, the development of anti-reflux mucosal intervention (ARMI), a novel strategy for treating GERD, has provided hope to such patients. ARMI comprises three main steps: Anti-reflux mucosectomy, anti-reflux mucosal ablation, and peroral endoscopic cardial constriction. ARMI involves the constriction of the pericardial mucosa through endoscopic surgery so as to reduce the damage caused by the reflux of gastric contents. This study compares different ARMI techniques, their therapeutic efficacy in treating GERD, indications and contraindications, endoscopic operational procedures, perioperative management, and adverse events, in an attempt to provide clinical guidance.