Cancer research and treatment
Excess Cholesterol Biosynthesis by Up-Regulated HMGCS1 in Colorectal Cancer Cells Induced M2-Like Tumor-Associated Macrophage Polarization Via Extracellular Vesicles.
Liu Yang, Bo Wu, Tingyi Sun, Haimei Sun, Jian Ma, Xiaohui Liu, Deshan Zhou, Shu Yang
Published: 202510.4143/crt.2025.550
Abstract
Purpose: The aetiology of colorectal cancer (CRC) is attributed to the intrinsic malignant cell transformation and the extrinsic tumor microenvironment (TME). Within the TME, M2-like tumor-associated macrophages (TAMs) play a pivotal role in promotin…
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