Modulating Propofol Requirement for Induction: The Impact of Different Time Intervals of Fentanyl Administration.

Background: The administration timing of fentanyl influences the required dose of propofol and its associated hemodynamic responses and side effects during anesthesia induction. Objectives: The objective is to determine the total propofol dose necessary for loss of consciousness during induction. Materials and Methods: This randomized study included 68 patients (`I) aged 18-65 years undergoing elective surgery under general anesthesia. Two groups were formed: Group A received fentanyl (2 mcg/kg) five minutes before propofol induction, while Group B received it 7 min prior. The required propofol dose and hemodynamic parameters were recorded. Data analysis was conducted using SPSS, with a P value < 0.05 considered statistically considerable. Results: Demographic characteristics were similar across both groups. Group A required a significantly higher propofol dose (86.77 mg ± 13.19 mg) than Group B (55.43 mg ± 13.01 mg). Incidence of movement (88.8% vs. 11.4%), vocalization (92.6% vs. 7.9%), and bucking (91.2% vs. 9.8%) were all higher in Group A (P < 0.0001). Hypotension was notably lower in Group B (6.1%) compared to Group A (93.7%; P < 0.0001). Conclusion: Administering fentanyl 7 min before propofol significantly reduces propofol dosage requirements and minimizes hypotension incidence during induction.