Impact of Hyaluronic Acid Around Dental Implants: A Systematic Review.

Aim: Hyaluronic acid (HA), a naturally occurring glycosaminoglycan, has gained attention in dental implantology due to its bioactive, anti-inflammatory, and wound-healing properties. This systematic review evaluates the current evidence regarding the application and efficacy of HA around dental implants, focusing on its impact on peri-implant tissue health, osseointegration, and prevention of peri-implant diseases. Materials and Methods: A comprehensive search was conducted across PubMed, Scopus, Embase, Cochrane Library, Google Scholar, and Web of Science databases for studies published from 2016 to 2024. Inclusion criteria: Encompassed human studies, animal studies, and in vitro studies. The Cochrane risk of bias 2 tool and the Newcastle-Ottawa Scale were used to assess the risk of bias. A total of 12 studies met the inclusion criteria. Results: It is demonstrated that HA application positively influences soft tissue healing, reduces inflammation, and may support early osseointegration. Despite promising findings, heterogeneity in HA formulations, application protocols, and follow-up durations limits the ability to draw definitive conclusions. Further long-term, standardized clinical trials are needed to validate its routine use in implant dentistry. Conclusion: This review highlights HA's potential as a valuable adjunct in implant therapy, especially for enhancing peri-implant tissue health and managing early peri-implant disease.