Oncology reportsHumansTumor MicroenvironmentBone NeoplasmsImmunotherapyOsteosarcoma
<p>Tumor microenvironment in bone sarcomas: Implications for immunotherapy and emerging therapeutic vulnerabilities (Review)</p>.
Wentao Li, Lijun Lv, Yibin Jin, Xin Yuan
Published: 202610.3892/or.2026.9050
Abstract
<p>Bone sarcomas remain lethal despite multimodal therapy, primarily because the mineralized, immunosuppressive tumor microenvironment (TME) promotes chemo‑ and immune‑resistance. Integrating single‑cell and spatial omics across osteosarcoma, Ewing s…
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