Journal of visualized experiments : JoVEHumansInduced Pluripotent Stem CellsFibroblast Growth FactorsToxicity TestsTeratogens
Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells.
Koki Murayama, Kashu Mizota, Rieko Matsuura, Yusuke Okubo, Yoshihiro Nakajima, Atsushi Suzuki, Junji Fukuda
Published: 202510.3791/68910
Abstract
Developmental toxicity (Devtox) is typically evaluated in animal models. However, there are challenges in ensuring accuracy, such as false negatives due to interspecies differences and ethical concerns regarding animal welfare. Therefore, there is a…
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