Journal of visualized experiments : JoVEfms-Like Tyrosine Kinase 3DNA DamageHumansComet AssayBenzothiazoles
Comet Assay to Quantify DNA Damage in FLT3 Mutant-expressing 32D Cells after Exposure to Type I and Type II FLT3 Inhibitors.
Jiani Ge, Yunfan Sun, Jingsheng Hua, Yuanhong Huang, Yi Wang, Dandan Tang, Taoyun Wang, Jinli Li, Yanfeng Deng, Song-Bai Liu
Published: 202510.3791/68469
Abstract
FMS-like tyrosine kinase 3 (FLT3), a class III receptor tyrosine kinase, exhibits a mutation frequency of approximately 30% in acute myeloid leukemia (AML) patients and constitutes a critical therapeutic target. As representative type I and type II F…
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