Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgeryHumansColorectal NeoplasmsProto-Oncogene Proteins p21(ras)MutationDrug Resistance
[Breakthroughs in KRAS G12C-mutant advanced colorectal cancer: from mechanisms to clinical practice].
J L Zou, Z Y Chen
Published: 202510.3760/cma.j.cn441530-441530-20250829-00321
Abstract
KRAS mutations are major oncogenic drivers in colorectal cancer (CRC), occurring in 35%-49% of cases; of which 3%-4% involve the KRAS G12C subtypes, characterized by a glycine-to-cysteine substitution at codon 12. This variant is associated with poor…
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