Zhonghua xin xue guan bing za zhiAnimalsMiceCheckpoint Kinase 1Oxidative StressCellular Senescence
[CHK1 attenuates cardiac senescence of mice through activating Rap1/Nox4 mediated oxidative stress homeostasis].
P Jing, L H Zhou, Y X Chen, L F Gu, C Du, T T Yang, S X Chen, H Wang, L S Wang
Published: 202510.3760/cma.j.cn112148-20241223-00804
Abstract
Objective: To investigate the biological role and molecular mechanism of checkpoint kinase 1 (CHK1) in delaying cardiac aging in mice. Methods: In vitro, a senescence model of H9C2 cells (a cardiomyocyte line) was induced using H2O2. A control group…
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