Acta biochimica et biophysica Sinica
RNF126 writes a non-canonical ubiquitin code on midnolin to tune protein stability.
Yun Yang, Jin Ren, Xiang Qiu, Yanlin Liu, Shilin Yuan, Ronggui Hu, Zhixiong Xia, Chuanyin Li
Published: 202610.3724/abbs.2025232
Abstract
Midnolin (MIDN) is a newly recognized master regulator that drives ubiquitin-independent proteasomal degradation, yet the mechanisms governing its own turnover remain enigmatic. Here, we demonstrate that MIDN is ubiquitinated and identify RNF126 as t…
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