Acta biochimica et biophysica Sinica
OAZ1/ CASP8AP2 double knockout enhances recombinant protein production in HEK293 cells through metabolic reprogramming and antiapoptotic effects.
Junhe Zhang, Liao Zhang, Lu Hou, Weidong Li, Shaolei Geng, Xiaoyin Wang, Tianyun Wang
Published: 202610.3724/abbs.2025196
Abstract
Human embryonic kidney (HEK) 293 cells are widely used for recombinant protein production because of their efficient posttranslational modification capabilities. However, their large-scale culture is often limited by metabolic stress and early apopto…
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