The impact of subgingival irrigation using ketorolac and chlorhexidine in patients with chronic periodontitis: A randomized, double-blind, controlled, clinical trial.

Background: Ketorolac is classified as a non-steroidal anti-inflammatory drug. It functions by inhibiting the production of prostaglandins, thereby diminishing the local inflammatory response. This medication has the potential to alleviate postoperative complications, including pain and swelling that may occur following surgical procedures. Methods: Fifty patients with mild chronic periodontitis were randomly divided into two blinded groups of 25 patients. One group underwent scaling and root planing (SRP) with 2% ketorolac trometamol (KT) irrigation, and the other group received 0.2% chlorhexidine (CHX). Treatment was performed on the first and second molars in both mandibular quadrants. Various clinical periodontal parameters, such as plaque index (PI), bleeding on probing (BOP), pocket probing depth (PPD), clinical attachment loss (CAL ), and gingival index (GI) were carefully recorded. Patients were scheduled for follow-up visits at 3-month intervals. Results: The CHX mouthwash and KT groups did not differ significantly in clinical periodontal parameters at baseline. Clinical outcomes demonstrated, as anticipated, statistically significant improvements in the percentages of PI, BOP, GI, PD, and CAL at 60 and 90 days compared to baseline in both groups (P<0.05). In contrast to the CHX group, the KT group's clinical periodontal parameters (PI, BOP, and GI) significantly decreased after the follow-up period. Conclusion: KT can be recommended as a complementary treatment for individuals suffering from chronic periodontitis, as it is more effective in reducing PI, GI, and BOP compared with CHX.