The Role of Cell Metabolism in Skin Wound Healing.

Since the skin is the largest organ of the human body, skin injuries may result in substantial social and economic burdens. Skin wound management remains a substantial challenge due to the complex nature of the healing process involving inflammation, tissue proliferation, and remodeling. Coordinated interactions between cells, extracellular matrices, and cytokines drive regeneration, while cell metabolism-an essential pillar of physiological activity-regulates key biological processes like proliferation, angiogenesis, immune responses, and tissue regeneration. Modulating metabolic pathways provides a promising alternative to conventional therapies. However, understanding of the role of cell metabolism in wound healing remains to be fully elucidated. Further exploration of their cross talk will not only establish a robust theoretical foundation for innovative treatments but also open avenues for promoting scar-minimizing regenerative healing and bringing new prospects for clinical practice.