Vaccine Hesitancy Toward Dengue Immunization Among Indonesian Office Workers: A Cross-Sectional Study of Perceptions, Barriers, and Trust Factors.

BACKGROUND/OBJECTIVES: In the absence of specific antiviral therapy for dengue viral infection, vaccination remains the most effective preventive measure. Two dengue vaccines have been licensed in Indonesia; however, concerns regarding vaccine hesitancy persist. This study aimed to assess dengue vaccine hesitancy among Indonesian office workers, comprising healthcare and non-healthcare workers. METHODS: A cross-sectional study with an online survey was conducted between February 1 and April 30, 2025. Eligible participants were adults (≥18 years) employed in office-based settings, including healthcare facilities. Questionnaires were disseminated through company management teams and included 37 items on demographic characteristics, vaccination intentions, and underlying motivations. Data were analyzed to identify determinants of vaccine hesitancy. RESULTS: A total of 377 respondents participated, the majority of whom were from West Java (335; 88.9%). One-third of respondents reported uncertainty regarding dengue vaccination (33.4% "not sure"), which was paralleled by hesitancy to pay for vaccination (43.2% "not sure"). Multivariable logistic regression analysis identified five significant determinants of vaccine hesitancy, with willingness-to-pay emerging as the strongest factor (β coefficient = 2.024; OR = 7.57; 95% CI = 4.06-14.10; p-value < 0.01). CONCLUSIONS: Approximately one-third of the surveyed Indonesian office workers exhibited hesitancy toward dengue vaccination. Willingness-to-pay was the most influential determinant of vaccine acceptance. Targeted strategies to address financial concerns and improve confidence in dengue vaccination are essential for strengthening workforce protection and national preparedness against dengue outbreaks.