VirusesAnimalsMicroRNAsHumansOncolytic VirotherapyOncolytic Viruses
Improved Safety of New MicroRNA-Regulated Oncolytic Coxsackievirus B3 Observed After Intravenous Administration in Colorectal-Tumor-Bearing Mice.
Leslie Elsner, Luisa Hinze, Ahmet Hazini, Lisanne Heimann, Anja Geisler, Babette Dieringer, Karin Klingel, Sophie Van Linthout, Jens Kurreck, Robert Klopfleisch, Henry Fechner
Published: 202610.3390/v18010143
Abstract
Oncolytic coxsackievirus B3 (oCVB3) strain PD-H has shown potent oncolytic efficacy and a remarkable safety profile in the treatment of colorectal cancer in vivo after intratumoral (i.t.) injection. In this study, we investigated the safety and effic…
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