VirusesPhosphorylationSARS-CoV-2Coronavirus Nucleocapsid ProteinsRNAViral
Mechanism of SARS-CoV-2 Nucleocapsid Protein Phosphorylation-Induced Functional Switch.
Megan S Sullivan, Michael Morse, Kaylee Grabarkewitz, Dina Bayachou, Ioulia Rouzina, Vicki Wysocki, Mark C Williams, Karin Musier-Forsyth
Published: 202610.3390/v18010105
Abstract
The SARS-CoV-2 nucleocapsid protein (Np) is essential for viral RNA replication and genomic RNA packaging. Phosphorylation of Np within its central Ser-Arg-rich (SRR) linker is proposed to modulate these functions. To gain mechanistic insights into t…
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