An Update of Phytotherapeutic Advances of Marigold (Calendula officinalis L.) in Wound Healing.

Wounds are disruptions of the dermal layer of the skin caused by physical, chemical, thermal, infectious, or immunological insults. Given the skin's critical role in maintaining homeostasis and protecting against external threats, prompt and effective wound healing is essential to restore functionality and prevent further complications. Numerous natural products (NPs) have long been employed in wound care due to their antioxidant, anti-inflammatory, antimicrobial, and regenerative properties. Building on this historical and scientific foundation, the present literature review consolidates and critically evaluates recent experimental and clinical evidence on the wound healing potential of marigold (Calendula officinalis L.). By focusing on studies published between 2020 and 2025, this review captures the evolving understanding of the plant's therapeutic applications, particularly in skin regeneration and wound management. For each selected publication, formulation type, intervention strategy, dosage, and key outcomes (such as healing rate, cell proliferation, and modulation of inflammatory markers) were summarized. This synthesis aims to provide an update on current evaluations involving C. officinalis and how this plant contributes to dermal repair and to identify promising directions for future research and clinical applications.