Pharmaceutics
In Silico Studies and Biological Evaluation of Thiosemicarbazones as Cruzain-Targeting Trypanocidal Agents for Chagas Disease.
Lidiane Meier, Milena F C V de Melo, Heitor R Abreu, Isabella M E Oliveira, Larissa Sens, Thiago H Doring, Renata Krogh, Adilson Beatriz, Adriano D Andricopulo, Sumbal Saba, Aldo S de Oliveira, Jamal Rafique
Published: 202610.3390/pharmaceutics18010065
Abstract
Background/Objectives: Chagas disease remains a major unmet medical need due to the limited efficacy and safety of current therapies. Here, we investigated sixteen thiosemicarbazone (TSC) derivatives as cruzain inhibitors using an integrated in silic…
Preview only. Read the full abstract at the source