Pharmaceutics
Boosting LNP Performance: Higher Concentrations of Lipid Mixtures Improve In Vivo Gene Expression and Storage Stability.
Blerina Shkodra, Ashish Muglikar, Janani Thangapandian, Matthias Schumacher, Burcu Binici, Yvonne Perrie
Published: 202510.3390/pharmaceutics18010050
Abstract
Background: An efficient formulation of lipid nanoparticles (LNPs) is often considered crucial in the successful development of nucleic acid therapeutics. This study explores the impact of varying the lipid and payload concentrations as starting mate…
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