Pharmaceuticals (Basel, Switzerland)
Integrative miRNA-mRNA Network and Molecular Dynamics-Based Identification of Therapeutic Candidates for Paroxysmal Nocturnal Hemoglobinuria.
Peng Zhao, Yujie Tang, Xin Sun, Yibo Xi, Haojun Zhang, Jia Xue, Wenqian Zhou, Hongyi Li, Xuechun Lu
Published: 202610.3390/ph19010143
Abstract
Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disease characterized primarily by intravascular hemolysis, thrombosis, and bone marrow failure. Complement inhibitors are commonly used in clinical treatment a…
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