Pharmaceuticals (Basel, Switzerland)
Development and Application of an LC-MS/MS Method for Simultaneous Quantification of Azathioprine and Its Metabolites: Pharmacokinetic and Microbial Metabolism Study of a Colon-Targeted Nanoparticle.
Jingjing Zhang, Jiaqi Han, Ning Sun, Yuhan Zhu, Dong Mei, Libo Zhao
Published: 202510.3390/ph19010058
Abstract
Background/Objectives: Given the clinical limitations of azathioprine (AZA) in treating inflammatory bowel disease, this study developed an AZA-loaded microbiota-modulating and colon-targeted nanoparticle constructed from pectin, Zein, and Eudragit®S…
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