Pharmaceuticals (Basel, Switzerland)
Development of Novel Proline- and Pipecolic Acid-Based Allosteric Inhibitors of Dengue and Zika Virus NS2B/NS3 Protease.
Josè Starvaggi, Carla Di Chio, Johannes Lang, Valentina Belgiovine, Daniela Trisciuzzi, Santo Previti, Christian Klein, Orazio Nicolotti, Salvatore Di Maro, Maria Zappalà, Roberta Ettari
Published: 202510.3390/ph19010024
Abstract
Background: In this study, we report a novel series of proline- and pipecolic acid-based small molecules designed as allosteric inhibitors of the NS2B/NS3 serine proteases from dengue and Zika viruses, key targets in antiviral drug discovery. Results…
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