Effects of Food Preferences and Supplement Intake During Pregnancy on the Cleft Lip and Palate Incidence: The Japan Environment and Children's Study.

BACKGROUND: Cleft lip and/or palate (CL/P) is a high-frequency congenital disease. Besides genetic background, maternal environmental factors may be involved in its incidence. We examined the effects of unbalanced diets and the intake of dietary supplements during pregnancy on the incidence of non-syndromic CL/P (NSCLP) via a case-control study design with multiple case groups. The case group diagnosed with NSCLP included 281 patients, 217 from the Japan Environment and Children's Study (JECS) data and 64 from the Aichi Gakuin University Hospital from 2011 to 2014. The control group comprised 87,477 (excluding cases with multiple births, chromosomal abnormalities, or complications) of the 104,062 fetal records registered in JECS. RESULTS: The results revealed a significantly increased risk of NSCLP (aOR 2.86, 95% CI 1.63-5.00) in mothers who avoided two or more food items out of the investigated five, i.e., milk and dairy products, eggs, soy, fish, and beef. No association was identified in mothers who avoided one food. CONCLUSIONS: Providing nutritional support when multiple foods are avoided in daily food habits may be effective in reducing the occurrence of NSCLP.