Nano-Enabled Agrochemicals for Heavy Metal Remediation in Agriculture: Current Status, Mechanisms, and Future Prospects.

Heavy metals (HMs) contamination in agricultural soils poses significant risks to crop production and human health through bioaccumulation in the food chain. While traditional remediation techniques exist, they often face limitations including high operational costs, low efficiency, and time-intensive processes. Nano-enabled agrochemicals have emerged as a promising solution for HM remediation in contaminated soils. In this review, we highlight distinct nano-enabled mechanisms involved in HMs remediation in agricultural soils. Further, this review describes HM remediation potential of three different classes of nano-agrochemicals exhibiting unique physicochemical properties, such as surface charge, controlled release capability, and metal chelating ability, etc. Nano-agrochemicals also enhance plant resilience through multiple pathways, such as the regulation of nutrient profiles and photosynthesis, activation of antioxidant defense systems, modulation of protein and osmolyte synthesis, stimulation of phytohormone pathways, and activation of stress-responsive transcription factors. While nano-agrochemicals show tremendous potential for sustainable agriculture, their environmental impact and safety considerations require careful assessment. The review highlights the need for continued research to fully understand nano-agrochemical interactions with plants and soil ecosystems, and to develop improved strategies for their safe and effective implementation in agricultural systems. Future studies should focus on optimizing nano-agrochemical formulations, investigating long-term effects, and establishing comprehensive risk assessment frameworks.