Molecules (Basel, Switzerland)Carbonic Anhydrase InhibitorsSulfonamidesClick ChemistryHumansCarbonic Anhydrases
Click Chemistry-Enabled Parallel Synthesis of N-Acyl Sulfonamides and Their Evaluation as Carbonic Anhydrase Inhibitors.
Oleksii V Gavrylenko, Bohdan V Vashchenko, Vasyl Naumchyk, Bohdan S Sosunovych, Oleksii Chuk, Oleksii Hrabovskyi, Olga Kuchuk, Alla Pogribna, Sergiy O Nikitin, Anzhelika I Konovets, Volodymyr S Brovarets, Sergey A Zozulya, Dmytro S Radchenko, Oleksandr O Grygorenko, Yurii S Moroz
Published: 202610.3390/molecules31020318
Abstract
A synthetically accessible library of N-acyl sulfonamides was constructed using a combination of copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and N-acylation of primary sulfonamides. The proposed two-step reaction sequence had a high experi…
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