Molecules (Basel, Switzerland)Histone DeacetylasesCatalytic DomainRepressor ProteinsMetalsDensity Functional Theory
Metal Preference Hierarchy in the HDAC8 Active Site: A DFT Study.
Nikolay Toshev, Diana Cheshmedzhieva, Yordanka Uzunova, Kristiyan Velichkov, Todor Dudev
Published: 202610.3390/molecules31020306
Abstract
HDAC8 is a histone deacetylase enzyme that plays a key role in the development of various diseases in humans, including cancers, neurodegenerative diseases, and alcohol use disorder. Although HDAC8 is classified as a Zn2+-dependent metalloenzyme, ava…
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