Microorganisms
Oral GAD65-L. lactis Vaccine Halts Diabetes Progression in NOD Mice by Orchestrating Gut Microbiota-Metabolite Crosstalk and Fostering Intestinal Immunoregulation.
Shihan Zhang, Xinyi Wang, Chunli Ma, Tianyu Liu, Qingji Qin, Jiandong Shi, Meini Wu, Jing Sun, Yunzhang Hu
Published: 202610.3390/microorganisms14010176
Abstract
This study successfully developed an oral vaccine for Type 1 Diabetes utilizing recombinant Lactococcus lactis expressing the GAD65 autoantigen. We conducted an in-depth investigation into its protective mechanisms in NOD mice, with a particular focu…
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