Engineering Thermal Cross-Linking in Nanofiltration Membranes for Efficient Nicotine Extraction from Tobacco Extract.

Tobacco extract contains numerous valuable components, among which nicotine possesses significant potential for high-value applications despite its well-known health risks. However, the efficient extraction of nicotine is challenging due to the complex composition of tobacco extracts and the limitations of conventional separation techniques. In this work, an integrally asymmetric nanofiltration membrane was developed via thermal cross-linking for highly efficient nicotine separation. A poly(aryl ether ketone) (PEK)-based ultrafiltration membrane was first prepared via non-solvent induced phase separation (NIPS), followed by controlled thermal cross-linking to tailor the membrane pore size toward the molecular weight of nicotine. To mitigate pore collapse and enhance flux, TiO2 nanoparticles were incorporated in situ through a sol-gel method. The resulting thermally cross-linked membrane exhibited a molecular weight cut-off of ~180 Da, a nicotine rejection rate of 93.2%, and a permeation flux of 143 L/(m2·h)-representing a 259% increase over the control membrane. Moreover, the thermally cross-linked membranes demonstrated exceptional chemical stability in various organic solvents and extreme pH conditions. This work offers a feasible and sustainable strategy for fabric high-performance nanofiltration membranes for the targeted extraction of bioactive molecules from complex plant extracts.