International journal of molecular sciencesSARS-CoV-2Molecular Dynamics SimulationCoronavirus 3C ProteasesMutationDrug Resistance
Mutation-Induced Resistance of SARS-CoV-2 Mpro to WU-04 Revealed by Multi-Scale Modeling.
Mengting Liu, Derui Zhao, Hui Duan, Junyao Zhu, Liting Zheng, Nan Yuan, Yuanling Xia, Peng Sang, Liquan Yang
Published: 202610.3390/ijms27021000
Abstract
The clinical durability of SARS-CoV-2 main protease (Mpro) inhibitors depends on their resilience to emerging resistance mutations. Recent genomic surveillance and functional reports have highlighted substitutions at positions 49, 165, and 301, raisi…
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