International journal of molecular sciencesSildenafil CitrateAnimalsPhosphodiesterase 5 InhibitorsMiceInflammation
Repurposing PDE5-Inhibitors: Sildenafil Drives Arteriogenesis via Localized Regenerative Inflammation.
Katharina Elbs, Lisa Bobrowski, Christoph Arnholdt, Matthias Kübler, Philipp Götz, Michael R Rohrmoser, Daphne Merkus, Manuel Lasch, Elisabeth Deindl
Published: 202610.3390/ijms27020985
Abstract
Arteriogenesis, the growth of pre-existing arterioles into functional collateral arteries, represents a key adaptive response to severe arterial stenosis. This process is driven by hemodynamic forces and a tightly coordinated inflammatory cascade. He…
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