International journal of molecular sciencesHumansColorectal NeoplasmsHydroxymethylglutaryl-CoA Reductase InhibitorsApoptosisHT29 Cells
Pharmacologic Modulation of the PAR-2-ERK Axis by Statins Converts Inflammatory Survival Signalling into Apoptosis in Colorectal Cancer Cells.
Layla Amiri, Rajashree Patnaik, Riah Lee Varghese, Bintul Huda, Yajnavalka Banerjee
Published: 202610.3390/ijms27020916
Abstract
Chronic inflammation constitutes a well-established driver of colorectal carcinogenesis, yet the molecular circuitry linking inflammatory receptor signalling to tumour cell survival remains incompletely delineated. Here we demonstrate that the HMG-Co…
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