International journal of molecular sciencesHumansFatigue SyndromeChronicReceptorsOpioid
Hypermethylation of OPRM1: Deregulation of the Endogenous Opioid Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia.
Arne Wyns, Jolien Hendrix, Jente Van Campenhout, Yanthe Buntinx, Huan-Yu Xiong, Elke De Bruyne, Lode Godderis, Jo Nijs, David Rice, Daniel Chiang, Andrea Polli
Published: 202610.3390/ijms27020826
Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia (FM) are debilitating disorders with overlapping symptoms such as chronic pain and fatigue. Dysregulation of the endogenous opioid system, particularly µ-opioid receptor fun…
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