Platinum Meets Pyridine: Affinity Studies of Pyridinecarboxylic Acids and Nicotinamide for Platinum-Based Drugs.

Since 1978, platinum-based drugs have benefited countless cancer patients and come to form the foundation of many cancer pharmacotherapies. These drugs induce apoptosis in cancer cells by forming cross-links between nucleobases in the DNA. Our previous studies have shown that these drugs can also interact with other similar compounds whose structures resemble nucleobases. Therefore, this study analyzed the interactions of Cisplatin, Carboplatin, and Oxaliplatin with Pyridine derivatives (Nicotinic acid, Nicotinamide, Isonicotinic acid, and Picolinic acid). These values were then compared with those for Guanine and Adenine coming from DNA using spectroscopic methods and computational chemistry (B3LYP/6-31G(d,p) and MN15/def2-TZVP methods). Theoretical studies suggest cytostatic affinity, not only for nucleobases but also for Pyridine derivatives. Experimental studies have confirmed these theoretical results.