Gels (Basel, Switzerland)
Rectal In Situ Thermosensitive Gel Loaded with Agomelatine-Silver Nanoparticles: Formulation and Characterization.
Marwa H Abdallah, Mohamed S Mohamed, Tamer M Shehata, Wael A Abdelhafez, Mahmoud M A Elsayed, Abd El Hakim Ramadan, Islam Kamal, Abdulsalam M Kassem, Mahmoud Elkot Mostafa, Ayman Salama, Reda A Mahmoud, Ahmed A El-Shenawy
Published: 202610.3390/gels12010051
Abstract
Agomelatine (AG) is a novel antidepressant characterized by distinct mechanism of action and minimal side effects. However, extensive first-pass hepatic metabolism limits its clinical efficacy after oral administration, leading to low bioavailability…
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