Gels (Basel, Switzerland)
Design and In Vitro Evaluation of Cross-Linked Poly(HEMA)-Pectin Nano-Composites for Targeted Delivery of Potassium Channel Blockers in Cancer Therapy.
Gizem Ozkurnaz Civir, Fatemeh Bahadori, Ozgur Ozay, Gamze Ergin Kızılçay, Seyma Atesoglu, Ebru Haciosmanoglu Aldogan, Burak Celik
Published: 202510.3390/gels12010013
Abstract
Potassium (K+) channel blockers are promising anticancer agents but suffer from off-target toxicities. We designed cross-linked poly-2-Hydroxyethyl methacrylate (HEMA)-pectin nanogels (HPN) to deliver two model blockers-dofetilide (Dof) and azimilide…
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