Advances in Multi-Omics Research on Biomarkers of Intrahepatic Cholangiocarcinoma.

Intrahepatic cholangiocarcinoma (iCCA) is a rare yet aggressive malignancy characterized by late-stage diagnosis and poor prognosis. Recent advancements in multi-omics technologies have significantly enhanced the understanding of the molecular features and complex biological mechanisms of iCCA. These approaches have revealed disease molecular heterogeneity and identified biomarkers linked to disease progression, patient prognosis, and therapeutic outcomes. This review synthesizes findings from multi-omics studies, highlighting their clinical implications and advancing the application of precision oncology in iCCA management.