CellsHumansSpheroidsCellularTumor MicroenvironmentCell Line
Three-Dimensional Tumor Spheroids Reveal B7-H3 CAR T Cell Infiltration Dynamics and Microenvironment-Induced Functional Reprogramming in Solid Tumors.
Feng Chen, Ke Ning, Yuanyuan Xie, Xiaoyan Yang, Ling Yu, Xinhui Wang
Published: 202610.3390/cells15020169
Abstract
Chimeric antigen receptor (CAR) T cell therapy has demonstrated clinical success in hematologic malignancies but has limited efficacy in solid tumors due to tumor microenvironment (TME) barriers that impede CAR T cell recognition, infiltration, and s…
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