Biomedicines
Hierarchical Network Organization and Dynamic Perturbation Propagation in Autism Spectrum Disorder: An Integrative Machine Learning and Hypergraph Analysis Reveals Super-Hub Genes and Therapeutic Targets.
Larissa Margareta Batrancea, Ömer Akgüller, Mehmet Ali Balcı, Lucian Gaban
Published: 202610.3390/biomedicines14010137
Abstract
Background/Objectives: Autism spectrum disorder (ASD) exhibits remarkable genetic heterogeneity involving hundreds of risk genes; however, the mechanism by which these genes organize within biological networks to contribute to disease pathogenesis re…
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